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In-vitro skin diffusion studies demonstrated a 5-fold increase in glutathione deposition compared to the free drug control

Edaravone, a synthetic free radical scavenger, showed potential by reducing reperfusion injury markers in a Phase II acute MI clinical trial (Tsujita et al., 2006)

Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, and Gottlieb E

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Some, such as calix[n]arenes, have demonstrated the ability to inhibit azobisisobutyronitrile-induced linoleic acid peroxidation, while others, like porphyrins, are effective in suppressing peroxidation processes in vivo

The DMF exerts its immuno-modulatory activity also via the agonism of the hydroxycarboxylic acid receptor 2 (38)